Apr 12, 2011 Abstract. Isomerization during grinding of solid-state α-monohydrate, α-anhydrate and β-anhydrate of lactose was investigated. Samples were ground in an agate centrifugal ball-mill at 270 rev min −1 at room temperature (20 C). The crystallinity of ground lactose was measured by Hermans' method from the powder X-ray diffraction profiles